ProtSuite Service Status
BLAST
UP
core
NCBI BLAST remote search
HMMER
UP
core
Pfam domain scan
Phobius
UP
core
Signal peptide and TM topology
CDD
UP
core
NCBI conserved domains
ScanProsite
UP
core
Patterns and functional sites
UniProtKB features
UP
core
Curated UniProt positional features for domains, motifs, regions, and sites
Coils
UP
core
Waggawagga coiled-coil prediction (Marcoil/Multicoil2/Ncoils/Paircoil2)
SMART
UP
experimental
Best-effort HTML parsing
InterProScan
UP
slow
Broad integrative annotation
SignalP
UP
core
DTU SignalP-5.0 — independent signal peptide cross-check for Phobius
DisorderPred
UP
companion
Companion disorder profile using NetSurf plus IUPred3 / ANCHOR2 comparison.
SSPred consensus
UP
companion
Optional secondary-structure consensus bundle using the SSPred service adapters.
Summary
Length
127 aa
Mol. Weight
12,784 Da
pI
4.49
GRAVY
-0.4575
Instability
43.89 (Unstable)
BLAST hits
7
Domains / motifs
4
Functional sites
0
TM helices
0
Signal peptide
No
Run profile: BLAST, HMMER, Phobius, CDD, ScanProsite, UniProtKB features, Coils, SMART, InterProScan, SignalP, DisorderPred, SSPred consensus
Likely 5-15 minutes depending on remote queues. SSPred companion waits on multiple external predictors.
Attached Companion Analyses
DisorderPred
READY
Mean disorder 0.8689 · disordered fraction 96.1%
2 disordered region(s) · 0 low-complexity segment(s)
SSPred consensus
READY
5 contributing predictors · mode majority vote
H 7.9% · E 0.0% · C 92.1%
Top BLAST Hit
CREB-binding protein
Homo sapiens
DisorderPred Companion
Mean disorder
0.8689
Disordered fraction
96.1%
Regions
2
Low complexity
0
Disordered regions
1–34
mean 0.8538
41–127
mean 0.905
Comparison predictors
IUPred3 long
OK
Mean 0.6906 · fraction 99.2%
IUPred3 short
OK
Mean 0.5859 · fraction 62.2%
ANCHOR2
OK
Mean 0.6906 · fraction 99.2%
SSPred Consensus Companion
Contributors
5
Helix
7.9%
Strand
0.0%
Coil
92.1%
Consensus prediction
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Consensus support
9777799999999999999999999999775555555799977799999977779999995555555557777559999999999999999999999999999999999999999999999999999
Contributing services
| Service | Status | Prediction |
|---|---|---|
| JPred | Complete | CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC… |
| PSI | Complete | CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH… |
| Sable | Complete | CHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHH… |
| SSPro | Error | Unexpected companion error: HTTPConnectionPool(host='scratch.proteomics.ics.uci.edu', port=80): Max retries exceeded with url: /cgi-bin/new_server/sql_predict.cgi (Caused by ConnectTimeoutError(<urllib3.connection.HTTPConnection object at 0x7698334c8160>, 'Connection to scratch.proteomics.ics.uci.edu timed out. (connect timeout=None)')) |
| Yaspin | Complete | CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC… |
| Predator | Error | Server returned HTTP 503 |
| NetSurf | Complete | CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC… |
Sequence Information
Description
CBP_1-127
Source
RAW
Sequence (127 aa)
MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGD
Physicochemical Properties
Length
127
MW (Da)
12783.89 Da
pI
4.49
GRAVY
-0.4575
Aromaticity
0.0236 (2.4%)
Instability Index
43.89
Helix fraction
0.315 (31.5%)
Sheet fraction
0.2126 (21.3%)
Turn fraction
0.5276 (52.8%)
Residue Composition
Program
blastpDatabase
SWISSPROTMax hits
10Returned
7
SwissProt is the curated section of UniProt — manually annotated, high-quality protein records. Hits here are reliable homologs.
Identity ≥60%: close ortholog | 30–60%: conserved family | <30%: distant or coincidental.
Identity ≥60%: close ortholog | 30–60%: conserved family | <30%: distant or coincidental.
BLAST Hits
Show columns:
| Accession | Protein | Organism | E-value | Identity | Coverage | Bit score |
|---|---|---|---|---|---|---|
| Q92793 | CREB-binding protein | Homo sapiens | 2.33e-77 | 100.0% | 100.0% | 641 |
| P45481 | Histone lysine acetyltransferase CREBBP | Mus musculus | 4.44e-72 | 95.3% | 100.0% | 602 |
| Q6JHU9 | Histone lysine acetyltransferase CREBBP | Rattus norvegicus | 4.11e-61 | 93.7% | 100.0% | 520 |
| B2RWS6 | Histone acetyltransferase p300 | Mus musculus | 3.06e-23 | 52.6% | 98.4% | 239 |
| Q09472 | Histone acetyltransferase p300 | Homo sapiens | 2.68e-22 | 51.1% | 99.2% | 232 |
| Q96N67 | Dedicator of cytokinesis protein 7 | Homo sapiens | 6.60e+00 | 68.8% | 12.6% | 66 |
| Q8R1A4 | Dedicator of cytokinesis protein 7 | Mus musculus | 7.05e+00 | 68.8% | 12.6% | 65 |
Identity: fraction of aligned positions that are identical. Coverage: query sequence fraction covered by the best alignment. E-value: expected alignments this good by chance; <1e-5 is highly significant. Bit score: normalized alignment quality independent of database size.
Pipeline — hits per source
| Source | Raw parsed | High-conf | Low-conf | Discarded | Final (deduped) |
|---|---|---|---|---|---|
| HMMER | 0 | 0 | 0 | 0 | 0 |
| Phobius | 0 | 0 | 0 | 0 | 0 |
| SignalP | 0 | 0 | 0 | 0 | 0 |
| CDD | 0 | 0 | 0 | 0 | 0 |
| ScanProsite | 1 | 1 | 0 | 0 | 1 |
| SMART | 4 | 3 | 0 | 1 | 3 |
| InterProScan | 0 | 0 | 0 | 0 | 0 |
| Waggawagga | 0 | 0 | 0 | 0 | 0 |
| Total | 5 | 4 | 0 | 1 | 4 |
Check annotations below, then click Generate Figure to build the domain architecture diagram.
Select annotations:
0 selected
E. Custom Annotations
▼
optional — write your own MyDomains commands
How to read and customize the domain architecture diagram
▼
A. Domain Architecture & Structural Features
?
| Program | Interval | Name / Accession | Evidence | Confidence | |
|---|---|---|---|---|---|
| ScanProsite | 69–127 | REKLES (PS51486) | PS51486 | — | |
| SMART | 47–59 | low complexity low-complexity | SMART low complexity | — | |
| SMART | 76–90 | low complexity low-complexity | SMART low complexity | — | |
| SMART | 96–106 | low complexity low-complexity | SMART low complexity | — |
B. Signal Sequence & Topology
No signal peptide or transmembrane helices detected.
C. Functional Sites
?
| Program | Position | Feature | Evidence | Confidence | |
|---|---|---|---|---|---|
| None detected. (Run ScanProsite or InterProScan to find ACT_SITE, DISULFID, BINDING residues.) | |||||
Pfam domain annotation was not run for this job.
Signal Peptide
?
Phobius
Not detected
SignalP-4.1
Not detected
✓ Both predictors agree: no signal peptide.
Transmembrane Topology
?
via Phobius (EBI)
TM Helices
0
Topology String
1-127 NON CYTOPLASMIC
No transmembrane helices detected.
Motif Search Results
Hits use 1-based residue numbering. A match shows that the pattern is present — it does not prove that the associated function is active in this protein.
HExxH
H-E-x(2)-H
No hits
No matches found in this sequence.
HExxH…E (neprilysin-type)
H-E-x(2)-H-x(20,80)-E
No hits
No matches found in this sequence.
CxxC
C-x(2)-C
No hits
No matches found in this sequence.
N-x-S/T (N-glycosylation)
N-x(1)-[ST]
2 hits
| # | Start | End | Length | Matched sequence |
|---|---|---|---|---|
| 1 | 25 | 27 | 3 | NDS |
| 2 | 88 | 90 | 3 | NVS |
R…S…E
R-x(0,200)-S-x(0,200)-E
1 hit
| # | Start | End | Length | Matched sequence |
|---|---|---|---|---|
| 1 | 14 | 72 | 59 | RAKLSSPGFSANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSE |
KDEL / HDEL (ER retention)
[KH]-D-E-L
No hits
No matches found in this sequence.
Coactivator Motif
LxxLL
1 hit
| # | Start | End | Length | Matched sequence |
|---|---|---|---|---|
| 1 | 70 | 74 | 5 | LSELL |
Sequence with highlighted motif locations
1
MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLV
61
PDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGK
121
SPLSQGD